Modulation of Morphine-induced Antinociception in Acute and Chronic Opioid Treatment by IbudilastLILIUS, Tuomas O; RAUHALA, Pekka V; KAMBUR, Oleg et al.Anesthesiology (Philadelphia). 2009, Vol 111, Num 6, pp 1356-1364, issn 0003-3022, 9 p.Article

Zl-n-91, a selective phosphodiesterase 4 inhibitor, suppresses inflammatory response in a COPD-like rat modelWANG, Ya-Juan; JIANG, Ya-Li; TANG, Hui-Fang et al.International immunopharmacology (Print). 2010, Vol 10, Num 2, pp 252-258, issn 1567-5769, 7 p.Article

Effects of the new benzimidazole derivative TAS-203, an orally active phosphodiesterase 4 inhibitor, on airway inflammation in rats and emetic responses in ferretsASAKA, Naomasa; KAKUO, Hiroyuki; OHMORI, Kouichi et al.Arzneimittel-Forschung. 2010, Vol 60, Num 9, pp 564-570, issn 0004-4172, 7 p.Article

The potential role of roflumilast : The new phosphodiesterase-4 inhibitorKARISH, Sarah B; GAGNON, James M.The Annals of pharmacotherapy. 2006, Vol 40, Num 6, pp 1096-1104, issn 1060-0280, 9 p.Article

Selective Inhibition of PDE4 in Wistar Rats Can Lead to Dilatation in Testis, Efferent Ducts, and Epididymis and Subsequent Formation of Sperm GranulomasHEUSER, Anke; MECKLENBURG, Lars; OCKERT, Deborah et al.Toxicologic pathology. 2013, Vol 41, Num 4, pp 615-627, issn 0192-6233, 13 p.Article

Myocardial and Reproductive System Toxicity of SCH 351591, a Selective Phosphodiesterase-4 Inhibitor, in CD-1 MiceLOSCO, Patricia E; POULET, Frederique M; KAMINSKA-MCNAMARA, Grazyna Z et al.Toxicologic pathology. 2010, Vol 38, Num 4, pp 568-582, issn 0192-6233, 15 p.Article

Phosphodiesterase 4 Inhibitors in Inflammatory Bowel Disease: A Comprehensive Review : New Treatments of Inflammatory Bowel Disease (IBD) Including Ulcerative Colitis and Crohn's Disease and Irritable Bowel Syndrome (IBS)SALARI-SHARIF, Pooneh; ABDOLLAHI, Mohammad.Current pharmaceutical design (Print). 2010, Vol 16, Num 33, pp 3661-3667, issn 1381-6128, 7 p.Article

Cilomilast : Orally active selective phosphodiesterase- 4 inhibitor for treatment of chronic obstructive pulmonary diseaseMARTINA, Shaunta D; ISMAIL, Maha S; VESTA, Kimi S et al.The Annals of pharmacotherapy. 2006, Vol 40, Num 10, pp 1822-1828, issn 1060-0280, 7 p.Article

Roflumilast: A Novel Treatment for Chronic Obstructive Pulmonary DiseaseREID, Debra J; PHAM, Nga T.The Annals of pharmacotherapy. 2012, Vol 46, Num 4, pp 521-529, issn 1060-0280, 9 p.Article

Phosphodiesterase 4 inhibitors in chronic obstructive pulmonary disease : a new approach to oral treatmentCURRIE, Graeme P; BUTLER, Claire A; ANDERSON, Wendy J et al.British journal of clinical pharmacology. 2008, Vol 65, Num 6, pp 803-810, issn 0306-5251, 8 p.Article

Effects of Andrographolide on the Pharmacokinetics of Aminophylline and Doxofylline in RatsLI, X. P; ZHANG, C. L; GAO, P et al.Drug research (Stuttgart. 2013. Print). 2013, Vol 63, Num 5, pp 258-262, issn 2194-9379, 5 p.Article

Randomized, placebo-controlled study of a selective PDE4 inhibitor in the treatment of asthmaLU, Susan; LIU, Nancy; BALACHANDRA DASS, S et al.Respiratory medicine. 2009, Vol 103, Num 3, pp 342-347, issn 0954-6111, 6 p.Article

The Role of Phosphodiesterases in Schizophrenia : Therapeutic ImplicationsSIUCIAK, Judith A.CNS drugs. 2008, Vol 22, Num 12, pp 983-993, issn 1172-7047, 11 p.Article

Cilomilast for COPD : Results of a 6-month, placebo-controlled study of a potent, selective inhibitor of phosphodiesterase 4RENNARD, Stephen I; SCHACHTER, Neil; STREK, Mary et al.Chest. 2006, Vol 129, Num 1, pp 56-66, issn 0012-3692, 11 p.Article

Preparation of azaindolines and benzoyl substituted azaindolines: precursors of triazabenzo[cd]azulen-9-one PDE4 inhibitorsBADLAND, Matthew; DEVILLERS, Ingrid; WRIGGLESWORTH, Roger et al.Tetrahedron letters. 2011, Vol 52, Num 41, issn 0040-4039, 5202, 5292-5296 [6 p.]Article

Recovery of respiratory activity after C2 hemisection (C2HS): Involvement of adenosinergic mechanismsNANTWI, Kwaku D.Respiratory physiology & neurobiology. 2009, Vol 169, Num 2, pp 102-114, issn 1569-9048, 13 p.Article

Roflumilast, a phosphodiesterase 4 inhibitor, reduces airway hyperresponsiveness after allergen challengeLOUW, C; WILLIAMS, Z; VENTER, L et al.Respiration (Basel). 2007, Vol 74, Num 4, pp 411-417, issn 0025-7931, 7 p.Article

Apremilast: First Global ApprovalPOOLE, Raewyn M; BALLANTYNE, Anita D.Drugs (Basel). 2014, Vol 74, Num 7, pp 825-837, issn 0012-6667, 13 p.Article

Efficacy of apremilast in the treatment of moderate to severe psoriasis: a randomised controlled trialPAPP, Kim; CATHER, Jennifer C; ROSOPH, Les et al.Lancet (British edition). 2012, Vol 380, Num 9843, pp 738-746, issn 0140-6736, 9 p.Article

Rhumatisme psoriasique: Résultats de l'ustekinumab et de l'apremilastPACCOU, Julien.Rhumatos. 2012, Vol 9, Num 83, pp 447-450, issn 1771-0081, 4 p.Article

Role of transporters in the disposition of the selective phosphodiesterase-4 inhibitor (+ ) -2 -[4 -({[2 -(benzo[1,3 ]dioxol -5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid in rat and humanKALGUTKAR, Amit S; BO FENG; DUIGNAN, David B et al.Drug metabolism and disposition. 2007, Vol 35, Num 11, pp 2111-2118, issn 0090-9556, 8 p.Article

Theophylline inhibits the cough reflex through a novel mechanism of actionDUBUIS, Eric; WORTLEY, Michael A; GRACE, Megan S et al.Journal of allergy and clinical immunology. 2014, Vol 133, Num 6, pp 1588-1598, issn 0091-6749, 11 p.Article

Ibudilast in healthy volunteers : safety, tolerability and pharmacokinetics with single and multiple dosesROLAN, Paul; GIBBONS, Jacqueline A; LIN HE et al.British journal of clinical pharmacology. 2008, Vol 66, Num 6, pp 792-801, issn 0306-5251, 10 p.Article

Low-dose theophylline restores corticosteroid responsiveness in rats with smoke-induced airway inflammationXIANWEN SUN; QINGYUN LI; YI GONG et al.Canadian journal of physiology and pharmacology. 2012, Vol 90, Num 7, pp 895-902, issn 0008-4212, 8 p.Article

Pd-mediated functionalization of polysubstituted pyrroles: Their evaluation as potential inhibitors of PDE4BHASKAR KUMAR, T; SUMANTH, Ch; SHIVA KUMAR, K et al.Bioorganic & medicinal chemistry letters (Print). 2012, Vol 22, Num 17, pp 5639-5647, issn 0960-894X, 9 p.Article